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The cognitive, psychomotorical and physical impact of malaria and other (infectious) diseases in school aged children


Malaria and anaemia are major causes of morbidity and mortality in children. Declining malaria has changed the shifted the burden of malaria to school children. Chemoprevention strategies using sulfadoxine-pyrimethamine (SP) was shown to prevent the incidence of malaria and anaemia in infants and school children in an area with low SP resistance. However, it is not clear whether this observation can be generalised to areas with high SP resistance. High levels of SP resistance are recorded in Eastern and Southern Africa and therefore alternative options needs evaluation as SP resistance continue to spread in the continent. There is, therefore, an urgent need to identify alternative drugs that could be used for IPTsc instead of SP. In addition , soil transmitted helminths co-morbidities continues to be unacceptably high in school-aged children, thus strategies for interrupting transmission needs to be optimized . We propose a randomized clinical trial to comparing the efficacy and safety of IPTc using dihydroartemisinin plus piperaquine and SP with piperaquine versus SP in high SP-resistance area.

Intervention type

TEAM projects


01/01/2017 - 31/12/2021

This project is being implemented in:
Flemish promoter Jean-Pierre Van geertruyden
Local promoter John Lusingu
Local partner institution Universiteit Antwerpen
visit www.uantwerpen.be
Local partner institution National Institute for Medical Research
Budget € 299.991